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Search Results for " insulin-like growth factor 1 "

Targets Recommended: Others

30

抑制剂 & 化合物

1

天然产物

1758

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1122L	IGF-I 30-41 acetate(82177-09-1 free base) Insulin-like Growth Factor I (30-41) acetate	Others	Others
	IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) 是胰岛素样生长因子 I (IGF-I) 的氨基酸 30 至 41 片段。
T6419	BMS-536924 HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117	Apoptosis; FAK; MEK; IGF-1R; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	BMS-536924 (BMS 536924) 是一种具有口服活性，竞争性和选择性的胰岛素样生长因子受体激酶和胰岛素受体抑制剂，IC50分别为 100 nM 和 73 nM。它具有抗癌活性。
TP1121	IGF-I (30-41) TFA(82177-09-1,FREE) Insulin-like Growth Factor I (30-41) (TFA)
	IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
T8906	NBI-31772 NBI31772,NBI 31772	IGF-1R	Tyrosine Kinase/Adaptors
	NBI-31772 (NBI 31772) 是胰岛素样生长因子-1 结合蛋白 (IGFBP, Ki = 47 nM) 的有效抑制剂。 NBI-31772 可用于 IGF 反应性疾病的研究。
T2349	BMS-754807	Trk receptor; c-Met/HGFR; IGF-1R	Tyrosine Kinase/Adaptors
	BMS754807 是一种可逆的IGF-1R 抑制剂 (IC50:1.8 nM，Ki<2 nM)，也是一种可逆的IR 抑制剂 (IC50:7 nM，Ki<2 nM)。它也抑制 Met (IC50:6 nM)，RON (IC50:44 nM)，TrkA (IC50:7 nM)，TrkB (IC50:4 nM)，AurA (IC50:9 nM) 和 AurB (IC50:25 nM) 的活性。
T76810	Ganitumab AMG 479	IGF-1R	Tyrosine Kinase/Adaptors
	Ganitumab (AMG 479) 是一种高效的1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 在低浓度下识别与 IGF1R 结合，KD 值为0.22 nM，Ganitumab 对小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用有抑制作用。Ganitumab 可用于研究癌症。
T6017	Linsitinib OSI-906,林西替尼	IGF-1R	Tyrosine Kinase/Adaptors
	Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂，IC50分别为 35 和 75 nM。
T68405	KW-2450 free base	IGF-1R	Tyrosine Kinase/Adaptors
	KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。
T25123	AZ12253801 AZ 12253801,AZ-12253801
	AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.
T70568	H-1356
	H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.
T24106	GSK2163632A GSK-2163632-A,GSK 2163632 A
	GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.
T25110	AS1069562 AS-1069562,AS 1069562
	AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake which acts by notably restoring reduced insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively.
T80871	Veligrotug	IGF-1R	Tyrosine Kinase/Adaptors
	Veligrotug为IgG1-kappa型抗IGF1R（胰岛素样生长因子1受体，CD221）嵌合单克隆抗体。
T30538	BMS-695735 CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888
	BMS-695735, a benzimidazole inhibitor of insulin-like growth factor-1 receptor, has broad-spectrum antitumor activity in vivo. It was found that BMS-695735 had strong inhibition of CYP3A4, induction of CYP3A4 mediated by PXR transactivation, poor water so
T76539	Insulin-like growth factor II
	Insulin-like growth factor II (IGF-2)为人血清中主要生长激素，对神经突生长具有许可性和直接作用，同时增强交感与感觉神经元的生存能力。
T38502	IGF-1R inhibitor-2
	IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R). By downregulating the IGF-1R, it has the potential to reverse the transformed phenotype of tumor cells and make them more susceptible to apoptosis.
T61506	NBI-31772 hydrate
	NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3].
T38584	ALK-IN-12
	ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (InsR), with IC50 values of 20.3 nM and 90.6 nM, respectively. Notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.
T75157L	Cimdelirsen sodium
	Cimdelirsen (sodium) 为针对肝脏的反义寡核苷酸，通过减少生长激素受体(GHr)合成，抑制生长激素(GH)的过度分泌效应，进而降低肢端肥大症患者体内循环胰岛素样生长因子-1 (IGF-1)水平。
T76043L	S961 acetate
	S961 acetate 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂，对 HIR-A，HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的 IC50分别为 0.048，0.027 和 630 nM。
T76043	S961 TFA
	S961 TFA为一种与胰岛素受体（insulin receptor, IR）高亲和力相结合的拮抗剂，其IC50值对HIR-A、HIR-B及人胰岛素样生长因子I受体（HIGF-IR）分别为0.048、0.027及630 nM。
T73702	Mecasermin
	Mecasermin（Human IGF-I; FK 780），一种重组人胰岛素样生长因子I（IGF-I），主要用于研究因生长激素（GH）受体缺陷或GH抑制抗体导致的GH不敏感性而引起的生长障碍。
T76759	Robatumumab
	Robatumumab (Sch 717454) 为针对人胰岛素样生长因子 1 受体(anti-humanIGF-1R)的抗体，展现出抗肿瘤及阻止癌细胞增殖的作用，适用于骨肉瘤与尤文肉瘤的研究。
T75157	Cimdelirsen
	Cimdelirsen为针对肝脏的反义寡核苷酸，通过降低生长激素受体(GHr)的合成量，来减少生长激素(GH)过量分泌所导致的不良影响，进而在肢端肥大症患者中降低循环胰岛素样生长因子-1(IGF-1)的水平。
T76746	Figitumumab
	Figitumumab (CP-751871) 为一种高效对抗胰岛素样生长因子 1 受体 (IGF1R) 的全人单克隆抗体。通过阻断 IGF1 与 IGF1R 的结合，其 IC50 值达到 1.8 nM。
T70876	KW-2450 Tosylate
	KW-2450 Tosylate is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 Tosylate selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in t...
T76012	IGF-I (30-41) (TFA)
	IGF-I (30-41) (TFA) 是类胰岛素生长因子I 30 至 41 的氨基酸片段。IGF-I 对生长激素的活性有着重要的作用，但是IGF-I 本身也具有一些自身的特性，如合成代谢、抗氧化、抗炎和细胞保护作用。
T76014	IGF-I (24-41) (TFA)
	IGF-I (24-41) TFA（Insulin-like Growth Factor I (24-41) TFA）是类胰岛素生长因子I的一个氨基酸片段，覆盖24至41位点。作为一种70个氨基酸组成的多肽激素，IGF-I TFA对神经元和神经胶质细胞具有营养作用，而且在调节全身生长激素（GH）活性中扮演关键角色。它还具备合成代谢、抗氧化、抗炎及细胞保护功能，对躯体生长及行为发育调节作用显著。
T76042	Angiopeptin TFA
	Angiopeptin TFA，一种生长抑素的环状八肽类似物，作为sst2/sst5受体部分激动剂，其IC50值为0.26 nM和6.92 nM。该化合物能够抑制生长激素释放及IGF-1(胰岛素样生长因子-1)的产生，同时抑制腺苷酸环化酶活性或刺激细胞外酸化。Angiopeptin TFA在冠状动脉粥样硬化的研究中显示出潜力。
T83825	Trofinetide acetate NNZ-2566
	Trofinetide是一种衍生自具有神经保护作用的三肽Gly-Pro-Glu的化合物，后者是胰岛素样生长因子-1（IGF-1）的N-端序列。在10 nM的浓度下使用时，它能减少由蛋白磷酸酶抑制剂奥卡达酸在原代大鼠胚胎纹状体神经元中引起的细胞死亡。Trofinetide在一种由穿透性弹道样脑损伤引起的大鼠神经炎症模型中减少了编码IL-1β、TNF-α、IL-6和E-selectin的mRNA的脑表达。在通过中脑动脉闭塞（MCAO）引起的大鼠脑损伤模型中，以30和60 mg/kg的剂量给药时，它减少了皮层和纹状体梗塞区域。Trofinetide（每天100 mg/kg）减少了树突棘的数量，并逆转了在fmr1-/-敲除小鼠脆性X综合征模型中的社交识别和情景恐惧条件反射的缺陷，同时也减少了睾丸重量的增加。含有Trofinetide的制剂已被用于治疗Rett综合征。

化合物

IGF-I 30-41 acetate(82177-09-1 free base)

Cat.No: TP1122L

Synonym: Insulin-like Growth Factor I (30-41) acetate

Target: Others

Cat.No: T6419

Synonym: HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117

Target: Apoptosis, FAK, MEK, IGF-1R, Src

IGF-I (30-41) TFA(82177-09-1,FREE)

Cat.No: TP1121

Synonym: Insulin-like Growth Factor I (30-41) (TFA)

Cat.No: T8906

Synonym: NBI31772,NBI 31772

Target: IGF-1R

Cat.No: T2349

Target: Trk receptor, c-Met/HGFR, IGF-1R

Cat.No: T76810

Synonym: AMG 479

Target: IGF-1R

Cat.No: T6017

Synonym: OSI-906,林西替尼

Target: IGF-1R

KW-2450 free base

Cat.No: T68405

Target: IGF-1R

Cat.No: T25123

Synonym: AZ 12253801,AZ-12253801

Cat.No: T70568

Cat.No: T24106

Synonym: GSK-2163632-A,GSK 2163632 A

Cat.No: T25110

Synonym: AS-1069562,AS 1069562

Cat.No: T80871

Target: IGF-1R

Cat.No: T30538

Synonym: CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888

Insulin-like growth factor II

Cat.No: T76539

IGF-1R inhibitor-2

Cat.No: T38502

NBI-31772 hydrate

Cat.No: T61506

Cat.No: T38584

Cimdelirsen sodium

Cat.No: T75157L

Cat.No: T76043L

Cat.No: T76043

Cat.No: T73702

Cat.No: T76759

Cat.No: T75157

Cat.No: T76746

KW-2450 Tosylate

Cat.No: T70876

IGF-I (30-41) (TFA)

Cat.No: T76012

IGF-I (24-41) (TFA)

Cat.No: T76014

Angiopeptin TFA

Cat.No: T76042

Trofinetide acetate

Cat.No: T83825

Synonym: NNZ-2566

Cat. No.	Product Name	Target	Signaling Pathways
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。

天然产物

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04878	IGF1/IGF-I Protein, Mouse, Recombinant insulin-like growth factor	Mouse	P. pastoris (Yeast)
	IGF1/IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.
TMPY-06982	IGF1/IGF-I Protein, Human, Recombinant insulin-like growth factor	Human	E. coli
	IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1.
TMPY-00834	IGF1R/CD221 Protein, Human, Recombinant (His) IGF-I R,IGFR,IGFIR,IGF1 Receptor,JTK13,	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
TMPY-02295	IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc) IGFBP-7,IGFBPRP1,IBP-7,TAF,FSTL2,PSF,insulin	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the accession number is Q16270.
TMPY-02533	IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) insulin-like growth factor	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q16270.
TMPY-02920	IGFBP-1 Protein, Rhesus, Recombinant (His) insulin-like growth factor	Rhesus	HEK293 Cells
	IGFBP-1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is A0A1D5QTL3.
TMPY-00080	IGFBP-1 Protein, Canine, Recombinant (His) insulin-like growth factor	Canine	HEK293 Cells
	IGFBP-1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A8C0MZD6.
TMPJ-00781	LR3-IGF-1 Protein, Mouse, Recombinant (His) IGF1,insulin-like growth...	Mouse	E. coli
	Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...
TMPY-06195	IGF1R/CD221 Protein, Mouse, Recombinant (His) insulin-like growth factor	Mouse	HEK293 Cells
	IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.
TMPY-04942	IGF1 LR3 Protein, Human, Recombinant IGF‑I,insulin-like growth fac...	Human	P. pastoris (Yeast)
	IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.
TMPY-06905	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated CD221,insulin-like growth	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 106.14 kDa and the accession number is NP_000866.1.
TMPY-04360	IGF1R/CD221 Protein, Human, Recombinant (His & GST) JTK13,insulin-like growth	Human	Baculovirus Insect Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
TMPJ-00811	IGFBP-1 Protein, Human, Recombinant (His) Insulin-like growth factor	Human	HEK293 Cells
	Insulin-like growth factor-binding protein 1 (IGFBP1) is encoded by 259 amino acid (aa) with 25 aa residue signal peptide that is processed to generate the 234 aa residue mature protein. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Regulation of Insulin-like Growth Factor (IGF) transp...
TMPJ-00658	CYR61/CCN1 Protein, Human, Recombinant (hFc) Cysteine-rich angiogenic inducer 61,IGFBP1...	Human	HEK293 Cells
	Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain and one VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 ...
TMPY-06649	IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated IGFBP-7v,IGFBP-7,MAC25,PSF,insulin-like	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.37 kDa and the accession number is Q16270.
TMPY-02296	IGFBP-7 Protein, Human, Recombinant (aa 1-282, His) TAF,IGFBP-7v,MAC25,IGFBP-7,FSTL2,PSF,IGFBPRP1,AGM,<...	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (aa 1-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is Q16270.
TMPY-06848	IGFBP-7 Protein, Human, Recombinant (K95R, His) PSF,MAC25,TAF,IBP-7,insulin-like growt...	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (K95R, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.59 kDa and the accession number is Q16270.
TMPY-06644	IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated AGM,IGFBP-7,FSTL2,RAMSVPS,PSF,IGFBPRP1,IBP-7,MAC25,...	Human	HEK293 Cells
	IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 54.98 kDa and the accession number is Q16270.
TMPH-02848	CYR61/CCN1 Protein, Mouse, Recombinant (His) CCN1,IGFBP-10,CCN family member 1...	Mouse	E. coli
	CYR61/CCN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is P18406.
TMPH-01068	CYR61/CCN1 Protein, Human, Recombinant (His & SUMO) IBP-10,GIG1,IGFBP-10,Insulin<...	Human	E. coli
	CYR61/CCN1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.4 kDa and the accession number is O00622.
TMPY-04552	AKT1 Protein, Human, Recombinant (His) RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1<...	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPK-00083	IGF1/IGF-I Protein, Human, Recombinant (hFc) IGF1A,胰岛素样生长因子,IBP1,IGF-I,MGF	Human	HEK293 Cells
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes.
TMPK-00061	IGF2/IGF-II Protein, Human, Recombinant (hFc) IGF2,IGF-II,PP1446,Somatomedin A,Somatomedin-A,胰岛素样...	Human	HEK293 Cells
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by ...
TMPJ-00164	IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated IBP-5,IBP5,IGF-Binding Protein 5,IGFBP5,Insulin-	Human	HEK293 Cells
	Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed...
TMPK-01353	IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi) CI-MPR,MPR 300,MPRI,M6P/IGF2R,M6PR,CD222,IGF-II receptor	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.50 kDa and the accession number is P11717.
TMPK-01355	IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi) IGF-II receptor,CI-MPR,CD222,M6P/IGF2R,MPRI,M6PR,MPR 300	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 117.40 kDa and the accession number is P11717.
TMPJ-01082	IGFBP-5 Protein, Mouse, Recombinant (His) IGFBP-5,IGF-binding protein 5,BP-5,Insulin-like...	Mouse	HEK293 Cells
	Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse IGFBP-5 shows 97% aa sequence identity with those of human and rat IGFBP-5. It is expressed mostly in kidney, uterus and gastrocnemius muscle. It also expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant PP9974,胰岛素样生长因子,C11orf43,IGF-II,insuli...	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...
TMPJ-01177	NOV/CCN3 Protein, Mouse, Recombinant (His) CCN family member 3,Nephroblastoma-overexpressed gene protei...	Mouse	HEK293 Cells
	NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and ...
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U...	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) AMPK, AMPK(α1, β1, γ1)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant CD3d molecule, δ (CD3-TCR complex),CD3-δ,CD3d molecule, delt...	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) Integrin alpha V β6,ITGAV & ITGB6,integrin, alpha 5 (fibrone...	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) CD3-DELTA,CD3d molecule, delta (CD3-TCR complex),CD3d molecu...	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi) ACE2,ACE-2,ACEH	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPY-04346	PD-L2 Protein, Human, Recombinant (His) PD-L2,B7-DC,CD273,Btdc,PDCD1L2,B7DC,PDL2,programmed...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
TMPY-00861	IL-33 Protein, Human, Recombinant IL1F11,C9orf26,NFEHEV,NF-HEV,DVS2...	Human	E. coli
	IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1.
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His) FLK2,FLK-2,CD135,STK1,fms-related tyrosine...	Human	HEK293 Cells
	FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
TMPY-01185	DR5/TRAIL R2 Protein, Human, Recombinant (His) KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis factor	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.
TMPY-05220	TSLP Protein, Human, Recombinant (R127A & R130S, His) thymic stromal lymphopoietin	Human	HEK293 Cells
	TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1.
TMPY-06418	R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) R-spondin 2,CRISTIN2	Human	HEK293 Cells
	R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.01 kDa and the accession number is Q6UXX9-1.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant FLT3LG,fms related tyrosine kinase 3 ligand,FLT3L,FL	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-04939	LAG-3 Protein, Human, Recombinant LAG-3,lymphocyte-activation gene 3,CD223	Human	HEK293 Cells
	LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
TMPY-04970	TIGIT Protein, Human, Recombinant (hFc) WUCAM,VSTM3,VSIG9,T cell immunoreceptor with Ig and ITIM dom...	Human	HEK293 Cells
	TIGIT Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is Q495A1-1.
TMPY-00947	VCAM-1 Protein, Human, Recombinant (hFc) INCAM-100,CD106,VCAM-1,vascular c...	Human	HEK293 Cells
	VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
TMPY-04165	FGFR3 Protein, Human, Recombinant (His) JTK4,CEK2,fibroblast growth factor recepto...	Human	HEK293 Cells
	FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1.
TMPY-03967	BTN3A3 Protein, Human, Recombinant (His) BTF3,BTN3.3,butyrophilin subfamily 3 member A3,BTN3A3	Human	HEK293 Cells
	BTN3A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is O00478-1.
TMPY-01949	CD19 Protein, Human, Recombinant (His) CD19 molecule,B4,CVID3	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1.
TMPY-05208	PD-L1 Protein, Human, Recombinant CD274 molecule,PDCD1L1,PD-L1,PDL<...	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.
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重组蛋白

IGF1/IGF-I Protein, Mouse, Recombinant

Cat.No: TMPY-04878

Species: Mouse

Expression System: P. pastoris (Yeast)

IGF1/IGF-I Protein, Human, Recombinant

Cat.No: TMPY-06982

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His)

Cat.No: TMPY-00834

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)

Cat.No: TMPY-02295

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)

Cat.No: TMPY-02533

Species: Human

Expression System: HEK293 Cells

IGFBP-1 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-02920

Species: Rhesus

Expression System: HEK293 Cells

IGFBP-1 Protein, Canine, Recombinant (His)

Cat.No: TMPY-00080

Species: Canine

Expression System: HEK293 Cells

LR3-IGF-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00781

Species: Mouse

Expression System: E. coli

IGF1R/CD221 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06195

Species: Mouse

Expression System: HEK293 Cells

IGF1 LR3 Protein, Human, Recombinant

Cat.No: TMPY-04942

Species: Human

Expression System: P. pastoris (Yeast)

IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06905

Species: Human

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04360

Species: Human

Expression System: Baculovirus Insect Cells

IGFBP-1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00811

Species: Human

Expression System: HEK293 Cells

CYR61/CCN1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00658

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06649

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (aa 1-282, His)

Cat.No: TMPY-02296

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (K95R, His)

Cat.No: TMPY-06848

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06644

Species: Human

Expression System: HEK293 Cells

CYR61/CCN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02848

Species: Mouse

Expression System: E. coli

CYR61/CCN1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01068

Species: Human

Expression System: E. coli

AKT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

IGF1/IGF-I Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00083

Species: Human

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00061

Species: Human

Expression System: HEK293 Cells

IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00164

Species: Human

Expression System: HEK293 Cells

IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01353

Species: Human

Expression System: HEK293 Cells

IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01355

Species: Human

Expression System: HEK293 Cells

IGFBP-5 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01082

Species: Mouse

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant

Cat.No: TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

NOV/CCN3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01177

Species: Mouse

Expression System: HEK293 Cells

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04451

Species: Human

Expression System: Baculovirus Insect Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant

Cat.No: TMPY-02501

Species: Human

Expression System: HEK293 Cells

Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-03878

Species: Human

Expression System: HEK293 Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-03745

Species: Human

Expression System: HEK293 Cells

ACE2/ACEH Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00383

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04346

Species: Human

Expression System: HEK293 Cells

IL-33 Protein, Human, Recombinant

Cat.No: TMPY-00861

Species: Human

Expression System: E. coli

FLT3 Protein, Human, Recombinant (T227M, His)

Cat.No: TMPY-01247

Species: Human

Expression System: HEK293 Cells

DR5/TRAIL R2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01185

Species: Human

Expression System: HEK293 Cells

TSLP Protein, Human, Recombinant (R127A & R130S, His)

Cat.No: TMPY-05220

Species: Human

Expression System: HEK293 Cells

R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06418

Species: Human

Expression System: HEK293 Cells

FLT3 Ligand Protein, Human, Recombinant

Cat.No: TMPY-06873

Species: Human

Expression System: E. coli

LAG-3 Protein, Human, Recombinant

Cat.No: TMPY-04939

Species: Human

Expression System: HEK293 Cells

TIGIT Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04970

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00947

Species: Human

Expression System: HEK293 Cells

FGFR3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04165

Species: Human

Expression System: HEK293 Cells

BTN3A3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03967

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (His)

Cat.No: TMPY-01949

Species: Human

Expression System: HEK293 Cells

PD-L1 Protein, Human, Recombinant

Cat.No: TMPY-05208

Species: Human

Expression System: HEK293 Cells

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